【医化学院】学术讲座系列：叶龙武教授关于divergent n-下载亚博app

报告题目

divergent n-heterocycle synthesis based on ynamides

报 告 人

厦门大学 叶龙武教授 青年长江学者、博导

报告时间

2018年11月30日下午15：00

报告地点

医化大楼c-230

报

告

内

容

简

介

ynamides are special alkynes attached to the nitrogen atom bearing an electron-withdrawing group, which provides enhanced stability. the electronic properties and the reactivity of ynamides can be easily tuned by the selection of the electron-withdrawing group attached to the nitrogen, thus making them highly versatile synthons. importantly, the nitrogen atom is able to impose an electronic bias, resulting in the highly regioselective attack of this electron-rich heteroatom-substituted alkyne by a large variety of nucleophiles. in our recent study on the use of heterosubstituted alkynes for heterocycle synthesis, we have realized an array of transition metal-catalyzed ynamide oxidation-, amination- and cycloisomerization-initiated tandem reactions, thus allowing the highly efficient and selective synthesis of versatile synthetically useful n-heterocycles.

承办学院

医药化工与材料工程学院

发布日期

2018年11月28日

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